Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC053
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-28 10:16
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment TBL MADOPAR 4X1\2 CAPS MADOPAR A 125MG 1 X1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 7 individuals with a value less than 0.53 were subsequently diagnosed with PD. That is, 16.67% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.53 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 22, 'TN': 17, 'TP': 20, 'FP': 13}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 37, 'TN': 27, 'TP': 5, 'FP': 3}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 24, 'TN': 20, 'TP': 18, 'FP': 10}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 15, 'TN': 9, 'TP': 27, 'FP': 21}

Test Battery Details

Circle

numCircles 11
timePerCircleMean 11.0727
timePerCircleCoV 0.449892
timePerCircleSlope -0.0294253
meanError 2.37438
tremorFreq 6.83594
tremorRelPower 34.8311
tremorGyroAmpMean 0.0215782
tremorGyroAmpSlope 0.0024898
tremorGyroAmpCoV 0.508118
tremorCoordAmpMean 0.0939375
tremorCoordAmpSlope -0.0116058
tremorCoordAmpCoV 2.36347
tremorAccAmpMean 0.0246341
tremorAccAmpSlope 0.00109382
tremorAccAmpCoV 0.385658
tremorPcRelVar 0.576488
tremorPcX -0.146141
tremorPcY 0.989264

Circle Segment 1

Duration 10.0 s, Accuracy Estimate 1.373 (lower is better)

Circle Segment 2

Duration 9.08 s, Accuracy Estimate 1.024 (lower is better)

Circle Segment 3

Duration 12.96 s, Accuracy Estimate 1.813 (lower is better)

Circle Segment 4

Duration 6.28 s, Accuracy Estimate 3.748 (lower is better)

Circle Segment 5

Duration 24.52 s, Accuracy Estimate 10.661 (lower is better)

Circle Segment 6

Duration 12.48 s, Accuracy Estimate 1.201 (lower is better)

Circle Segment 7

Duration 12.48 s, Accuracy Estimate 1.256 (lower is better)

Circle Segment 8

Duration 10.12 s, Accuracy Estimate 1.282 (lower is better)

Circle Segment 9

Duration 9.0 s, Accuracy Estimate 1.203 (lower is better)

Circle Segment 10

Duration 7.68 s, Accuracy Estimate 1.378 (lower is better)

Circle Segment 11

Duration 7.2 s, Accuracy Estimate 1.179 (lower is better)

Spiral

numSpirals 9
timePerSpiralMean 25.4756
timePerSpiralCoV 0.161765
timePerSpiralSlope 0.0027739
meanError 1.7235
tremorFreq 6.93359
tremorRelPower 46.968
tremorGyroAmpMean 0.0294786
tremorGyroAmpSlope -0.000439665
tremorGyroAmpCoV 0.584081
tremorCoordAmpMean 0.0442224
tremorCoordAmpSlope -0.000293092
tremorCoordAmpCoV 0.424245
tremorAccAmpMean 0.0290882
tremorAccAmpSlope -0.000203172
tremorAccAmpCoV 0.457171
tremorPcRelVar 0.746704
tremorPcX -0.869657
tremorPcY 0.493657

Spiral Segment 1

Duration 30.48 s, Accuracy Estimate 1.45 (lower is better)

Spiral Segment 2

Duration 21.56 s, Accuracy Estimate 1.632 (lower is better)

Spiral Segment 3

Duration 22.72 s, Accuracy Estimate 1.691 (lower is better)

Spiral Segment 4

Duration 23.36 s, Accuracy Estimate 1.926 (lower is better)

Spiral Segment 5

Duration 23.84 s, Accuracy Estimate 1.937 (lower is better)

Spiral Segment 6

Duration 29.44 s, Accuracy Estimate 1.694 (lower is better)

Spiral Segment 7

Duration 24.56 s, Accuracy Estimate 1.764 (lower is better)

Spiral Segment 8

Duration 32.2 s, Accuracy Estimate 1.91 (lower is better)

Spiral Segment 9

Duration 21.12 s, Accuracy Estimate 1.508 (lower is better)

Elel

eDurationMean 0.571047
eDurationStd 0.182723
eDurationStdnorm 0.319979
eDurationMedian 0.535
eDurationQuartdelta 0.28
eDurationQuartdeltanorm 0.523364
eDurationKurt 2.39624
eDurationTrenddiff -0.275
eDurationTrendratio 0.607143
eWidthMean 4.78612
eWidthStd 1.84054
eWidthStdnorm 0.384558
eWidthMedian 4.329
eWidthQuartdelta 2.574
eWidthQuartdeltanorm 0.594595
eWidthKurt 3.44377
eWidthTrenddiff -0.936
eWidthTrendratio 0.8
eHeightMean 8.6063
eHeightStd 4.45042
eHeightStdnorm 0.517112
eHeightMedian 7.605
eHeightQuartdelta 7.02
eHeightQuartdeltanorm 0.923077
eHeightKurt 2.78376
eHeightTrenddiff -6.903
eHeightTrendratio 0.391753
eAspectMean 0.637617
eAspectStd 0.247064
eAspectStdnorm 0.38748
eAspectMedian 0.604651
eAspectQuartdelta 0.292676
eAspectQuartdeltanorm 0.484041
eAspectKurt 5.77982
eAspectTrenddiff 0.236096
eAspectTrendratio 1.45345
eSlantMean 0.189561
eSlantStd 0.153972
eSlantStdnorm 0.812259
eSlantMedian 0.180952
eSlantQuartdelta 0.133624
eSlantQuartdeltanorm 0.73845
eSlantKurt 5.77159
eSlantTrenddiff 0.00654762
eRtopMean 0.764296
eRtopStd 0.125663
eRtopStdnorm 0.164416
eRtopMedian 0.793651
eRtopQuartdelta 0.193094
eRtopQuartdeltanorm 0.243299
eRtopKurt 2.04239
eRtopTrenddiff -0.14245
eRbotMean 0.466033
eRbotStd 0.151023
eRbotStdnorm 0.324061
eRbotMedian 0.454545
eRbotQuartdelta 0.0947337
eRbotQuartdeltanorm 0.208414
eRbotKurt 8.41787
eRbotTrenddiff 0.04375
eRrightMean 0.855309
eRrightStd 0.11623
eRrightStdnorm 0.135893
eRrightMedian 0.893333
eRrightQuartdelta 0.191196
eRrightQuartdeltanorm 0.214025
eRrightKurt 3.56262
eRrightTrenddiff -0.166297
eRleftMean 0.282794
eRleftStd 0.106663
eRleftStdnorm 0.377174
eRleftMedian 0.272727
eRleftQuartdelta 0.111106
eRleftQuartdeltanorm 0.40739
eRleftKurt 2.97287
eRleftTrenddiff -0.0122172
lDurationMean 0.721667
lDurationStd 0.181261
lDurationStdnorm 0.251171
lDurationMedian 0.6825
lDurationQuartdelta 0.225
lDurationQuartdeltanorm 0.32967
lDurationKurt 3.21974
lDurationTrenddiff -0.135
lDurationTrendratio 0.823529
lWidthMean 7.78886
lWidthStd 1.26625
lWidthStdnorm 0.162571
lWidthMedian 7.5465
lWidthQuartdelta 1.521
lWidthQuartdeltanorm 0.20155
lWidthKurt 4.29196
lWidthTrenddiff -0.234
lWidthTrendratio 0.969697
lHeightMean 23.9878
lHeightStd 2.45673
lHeightStdnorm 0.102416
lHeightMedian 23.751
lHeightQuartdelta 3.159
lHeightQuartdeltanorm 0.133005
lHeightKurt 3.51321
lHeightTrenddiff -0.351
lHeightTrendratio 0.985294
lAspectMean 0.326668
lAspectStd 0.0561198
lAspectStdnorm 0.171794
lAspectMedian 0.328955
lAspectQuartdelta 0.0627748
lAspectQuartdeltanorm 0.190831
lAspectKurt 7.10359
lAspectTrenddiff 0.010582
lAspectTrendratio 1.03279
lSlantMean 0.119504
lSlantStd 0.0678031
lSlantStdnorm 0.567373
lSlantMedian 0.11506
lSlantQuartdelta 0.0853233
lSlantQuartdeltanorm 0.741556
lSlantKurt 2.78561
lSlantTrenddiff 0.0136467
lRtopMean 0.893886
lRtopStd 0.0545583
lRtopStdnorm 0.0610349
lRtopMedian 0.897486
lRtopQuartdelta 0.0727833
lRtopQuartdeltanorm 0.0810968
lRtopKurt 2.9163
lRtopTrenddiff 0.0395833
lRbotMean 0.537487
lRbotStd 0.170752
lRbotStdnorm 0.317686
lRbotMedian 0.5
lRbotQuartdelta 0.209704
lRbotQuartdeltanorm 0.419408
lRbotKurt 3.60815
lRbotTrenddiff -0.0272904
lRrightMean 0.953176
lRrightStd 0.0269181
lRrightStdnorm 0.0282404
lRrightMedian 0.955205
lRrightQuartdelta 0.0360798
lRrightQuartdeltanorm 0.0377717
lRrightKurt 4.00387
lRrightTrenddiff -0.006585
lRleftMean 0.255692
lRleftStd 0.08507
lRleftStdnorm 0.332705
lRleftMedian 0.237005
lRleftQuartdelta 0.133725
lRleftQuartdeltanorm 0.564231
lRleftKurt 2.84752
lRleftTrenddiff -0.00462236

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.931142
sumTouchScores 20.4851
meanMovementTime 0.735
numTouches 22
undershootPercentage 0
overshootPercentage 9.09091

FITTS Long Modified

meanTouchScore 0.97934
sumTouchScores 10.7727
meanMovementTime 1.384
numTouches 11
undershootPercentage 0
overshootPercentage 9.09091

ZigZag

numZigzags 5
timePerZigzagMean 20.016
timePerZigzagCoV 0.223095
timePerZigzagSlope -0.0715428
meanError 1.89328
tremorFreq 6.64062
tremorRelPower 28.9416
tremorGyroAmpMean 0.0229286
tremorGyroAmpSlope 0.000647622
tremorGyroAmpCoV 0.360406
tremorCoordAmpMean 0.052184
tremorCoordAmpSlope 0.0014736
tremorCoordAmpCoV 0.286874
tremorAccAmpMean 0.0341326
tremorAccAmpSlope 0.00239999
tremorAccAmpCoV 0.290106
tremorPcRelVar 0.672855
tremorPcX 0.252192
tremorPcY 0.967677

ZigZag Segment 1

Duration 27.52 s, Accuracy Estimate 1.759 (lower is better)

ZigZag Segment 2

Duration 17.44 s, Accuracy Estimate 2.074 (lower is better)

ZigZag Segment 3

Duration 17.68 s, Accuracy Estimate 1.901 (lower is better)

ZigZag Segment 4

Duration 16.72 s, Accuracy Estimate 1.856 (lower is better)

ZigZag Segment 5

Duration 20.72 s, Accuracy Estimate 1.876 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 12.376
timePerZigzagCoV 0.193095
timePerZigzagSlope -0.105688
zigzagHeightMean 64.1731
zigzagHeightCoV 0.0326207
zigzagHeightSlope 0.00320842
meanError 0.0400429
tremorFreq 6.54297
tremorRelPower 30.626
tremorGyroAmpMean 0.0302498
tremorGyroAmpSlope 0.00385026
tremorGyroAmpCoV 0.362497
tremorCoordAmpMean 0.0747527
tremorCoordAmpSlope 0.00539611
tremorCoordAmpCoV 0.242631
tremorAccAmpMean 0.0479195
tremorAccAmpSlope 0.00581332
tremorAccAmpCoV 0.324965
tremorPcRelVar 0.781891
tremorPcX -0.114428
tremorPcY -0.993432

ZigZag Offset Segment 1

Duration 16.36 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 2

Duration 12.12 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 3

Duration 11.56 s, Accuracy Estimate 0.032 (lower is better)

ZigZag Offset Segment 4

Duration 11.92 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 5

Duration 9.92 s, Accuracy Estimate 0.073 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.79}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.53}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.6546544671071615}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.6338888945006702}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5451176313235797}